Metabolic Disease

Aloe-emodin-8-O-β-D-glucopyranoside (Standard) is the analytical standard of Aloe-emodin-8-O-β-D-glucopyranoside. This product is intended for research and analytical applications. Aloe-emodin-8-O-β-D-glucopyranoside, a compound isolated from Saussrurea lappa, is a moderate inhibitor of human protein tyrosine phosphatase 1B (hPTP1B) with an IC₅₀ of 26.6 μM.

Bisphenol F-¹³C₁₂ is the ¹³C labeled Bisphenol F (HY-W014901). Bisphenol F is an orally active endocrine disruptor. Bisphenol F promotes ROS generation, upregulates p-AKT/p-GSK3β, and induces Apoptosis. Bisphenol F interferes with glucose metabolism, affects neurodevelopment and reproductive function. Bisphenol F reduces social novelty preference in mouse offspring. Bisphenol F can be used in bone, blood, and fat-related studies. Bisphenol F is used as a substitute for Bisphenol A (HY-18260).

Soyasaponin Bb (Standard) is the analytical standard of Soyasaponin Bb (HY-N0310). This product is intended for research and analytical applications. Soyasaponin Bb is an orally active, covalent inducer of heme oxygenase HO-1 and an inhibitor of aldose reductase AKR1B1. Soyasaponin Bb can regulate oxidative stress pathways, enhance antioxidant capacity, reduce reactive oxygen species (ROS) generation, and inhibit lipid peroxidation and hepatocyte apoptosis. Soyasaponin Bb improves alcohol-induced hepatocyte membrane damage and liver function abnormalities, and improves Scopolamine (HY-N0296)-induced memory impairment. Soyasaponin Bb has antioxidant, hepatoprotective, and neuroprotective activities.

N-Heptadecane (Standard) is the analytical standard of N-Heptadecane. This product is intended for research and analytical applications. N-Heptadecane (Heptadecane) is an ester product.

Myristylmyristate (Tetradecyl tetradecanoate) is an ester product.

5-Pregnene-3β,17a,20a-triol is an endogenous steroid compound. 5-Pregnene-3β,17a,20a-triol plays a role in maintaining the body's hormonal balance. 5-Pregnene-3β,17a,20a-triol is promising for research of congenital steroid synthesis enzyme deficiency diseases.

SCH 900822 is a potent and selective glucagon receptor (hGCGR) antagonist that blocks the binding of glucagon to its receptor, thereby reducing hepatic glycogenolysis and gluconeogenesis, thereby lowering blood glucose production. SCH 900822 can be used in the study of type 2 diabetes.

GLP-1R Antagonist 1 (Standard) is the analytical standard of GLP-1R Antagonist 1 (HY-101116). This product is intended for research and analytical applications. GLP-1R Antagonist 1 (compound 5d) is an orally active, CNS penetrant and non-competitive antagonist of glucagon-like peptide 1 receptor (GLP-1R), with an IC50 of 650 nM.

Ethyl 12(Z)-heneicosenoate is an ester product.

CLX-0921 is an orally active PPARγ agonist with an IC₅₀ of 1.54 μM. CLX-0921 has a potent antihyperglycemic activity, and can be used for the study of type 2 diabetes.

ASP4000 free base is an orally effective dipeptidyl peptidase 4 (DPP4) inhibitor, with an IC₅₀ value of 2.25 nM against human recombinant DPP4, and exhibits hypoglycemic activity. By inhibiting DPP4 activity, ASP4000 free base reduces the degradation of active glucagon-like peptide-1 (GLP-1), thereby persistently increasing postprandial active GLP-1 levels and improving glycemic control. ASP4000 free base can be used in studies related to type 2 diabetes.

Methyl 3-hydroxyoctadecanoate is an ester product.

G6PDi-1 (Standard) is the analytical standard of G6PDi-1 (HY-W107464). This product is intended for research and analytical applications. G6PDi-1 is a reversible and non-competitive glucose-6-phosphate dehydrogenase (G6PD) inhibitor with an IC₅₀ of 0.07 μM for human G6PD. G6PDi-1 depletes NADPH most strongly in lymphocytes. G6PDi-1 markedly decreases inflammatory cytoK_ine production in T cells.

3'-ONH?-dCTP is a monomeric raw material that can be used for nucleic acid synthesis.

Tetracosanoyl chloride is an ester product.

1-Olein-3-butyrin is an acylglycerol.

6,6′-Trehalose dioleate is a glycolipid that can be used to prepare lipid nanoparticles (LNPs) for drug delivery.

Xylobiose (1,4-β-D-Xylobiose; 1,4-D-Xylobiose) is an orally active Claudin 2/CLDN2 inhibitor and HSP27 inducer. Xylobiose works by regulating intestinal barrier function and glucose and lipid metabolism-related signaling pathways. Xylobiose inhibits CLDN2 expression to reduce intestinal permeability, induces HSP27 to enhance cell protection, and regulates the miR-122a/miR-33a axis to inhibit liver lipid synthesis and improve insulin resistance. Xylobiose can strengthen intestinal barrier integrity, reduce blood sugar and blood lipid levels, and reduce oxidative stress and inflammatory response. Xylobiose can be used in the study of type 2 diabetes and metabolic syndrome.

Clobetasone propionate is a corticosteroid. Formulations containing clobetasol propionate have been used in the treatment of eczema, psoriasis, and lupus.

(+)-Kavain (Standard) is the analytical standard of (+)-Kavain. This product is intended for research and analytical applications. (+)-Kavain, a main kavalactone extracted from Piper methysticum, has anticonvulsive properties, attenuating vascular smooth muscle contraction through interactions with voltage-dependent Na+ and Ca2+ channels. (+)-Kavain is shown to bind at the α4β2δ GABAA receptor and potentiate GABA efficacy. (+)-Kavain is used as a treatment for inflammatory diseases, its anti-inflammatory action has been widely studied.